解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVES:The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821fcdcf
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Nuclear factor κB (NF-κB) plays an intrinsic role in promoting growth, angiogenesis, and metastasis in pancreatic cancer (PC) and serves as a mechanism underlying therapeutic resistance. Accordingly, we investigated the efficacy of bioactive phytochemicals in inhibiting radiotherapy (RT)-induced NF-κB activi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821f677d
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821bd62f
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is the main diagnostic modality for pancreatic mass lesions. However, cytology is often indeterminate, leading to repeat FNAs and delay in care. Here, we evaluate whether combining routine cytology with fluorescence in situ hybridization (FISH) ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182200201
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to compare the development of murine embryonic pancreas in vitro and in vivo. METHODS:Murine embryonic pancreas at 12.5 days of gestation was dissected and cultured at the air-medium interface. At 1, 3, and 7 days of culture, the characteristics of cultured murine pancre...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821ad758
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e3182258a15
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821f6b14
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Pancreatic stellate cells (PSCs) are important players in pancreatic fibrosis and are major contributors to the extracellular matrix proteins observed with the stromal response characteristic of pancreatic ductal adenocarcinoma (PDAC). Pancreatic stellate cells are also believed to secrete soluble factors tha...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318214efaf
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318205eb03
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182016a08
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318201654a
更新日期:2011-03-01 00:00:00
abstract:UNLABELLED:OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS:We assess the cli...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3181f95104
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Pancreatic functions were determined in a Ki-ras-induced actin-interacting protein (KRAP)-deficient (-/-) mouse mutant. METHODS:Pancreatic enzyme, protein, and DNA contents were measured, and histological examinations were conducted. The mixture of bile-pancreatic juice was collected, and amylase and bile a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181f66c22
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181f74ad7
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181e89f74
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To establish new biomarkers for accurate diagnosis of pancreatic cancer (PC) using a standardized serum peptidome profiling and compare the results with those from the tumor marker, CA 19-9. METHODS:Serum samples from 102 patients (55 with chronic pancreatitis and 47 with PC) and 56 healthy controls were col...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dfcbe5
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:Thymidylate synthase (TS) inhibitors activate human equilibrative nucleoside transporter 1. We evaluated the contribution of TS expression to determine a treatment method providing an effect from gemcitabine (GEM). METHODS:The expression of 5-fluorouracil (5-FU) and GEM metabolic factors (5-FU: TS, dihydrop...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dec17d
更新日期:2010-11-01 00:00:00
abstract::Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181f66cdf
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:To investigate the performance of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for predicting severe acute pancreatitis (AP). METHODS:Fifty patients with AP were prospectively enrolled. Erythrocyte sedimentation rate and CRP were measured at admission and every 12 hours for 48 hours aft...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181deb33e
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d7ace1
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d705d4
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dab19a
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Adhesion molecules are involved in the inflammatory response during acute pancreatitis (AP). We investigated the effect of dexamethasone (Dx) on intercellular adhesion molecule 1 (ICAM-1) expression during AP and its consequences on leukocyte recruitment and pancreatic damage. METHODS:Acute pancreatitis was...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181da0f3e
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:The present study was conducted to monitor the expression of pancreas and duodenal homeobox gene (PDX-1) for assessing beta-cell function in islets from patients with chronic pancreatitis (CP). METHODS:Islets isolated from the pancreata of 40 surgical patients categorized as control group, patients with mil...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d6bc69
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d3645b
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181ce719e
更新日期:2010-08-01 00:00:00
abstract::Neuroendocrine tumors (NETs) arise in most organs of the body and share many common pathologic features. However, a variety of different organ-specific systems have been developed for nomenclature, grading, and staging of NETs, causing much confusion. This review examines issues in the pathologic assessment of NETs th...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181ec124e
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c6575d
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas include neoplasms with varying likelihood of progression to malignancy. The aim of this study was to investigate a natural course of main duct IPMNs with a lower likelihood of malignancy. METHODS:Twenty main duct IPMNs with a lower l...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c81b52
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c314b3
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd6470
更新日期:2010-05-01 00:00:00
abstract::Clinical and translational research is critical for the development of improvement in care of pancreatic diseases. Major concerns are the lack of dedicated trainees in pancreatic research and the difficulty for the remaining trainees to develop independent research careers to be included into the pancreas research com...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c63422
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the efficacy of a pancreatic stent regarding the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms. METHODS:A retrospective stud...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bb8da1
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To study the association of binge drinking and the outcomes of severe acute pancreatitis (SAP). METHODS:This retrospective study included 347 patients with first-attack SAP from January 2001 to February 2004. On the basis of the history of binge drinking or not, the patients were divided into the alcohol (n...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181baeae6
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd672c
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181baac47
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3181bc0f85
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB). This study investigates the effect of GTPs in a cerulein-induced murine model of acute pancreatitis (AP). METHODS:Male CD mice (median weight,...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181b28d11
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:To provide histologic correlation of endoscopic ultrasound (EUS) findings believed to represent chronic pancreatitis (CP). METHODS:Eighteen postmortem pancreatic specimens in patients dying of all causes were examined in vitro by EUS for features of CP: (1) echogenic foci, (2) hypoechoic foci, (3) echogenic...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181b2bc1a
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides. METHODS:The effects of antisense to miR-21 and miR-221 on cell proliferation, cell cycle arrest, induction of apoptosis, combinat...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181ba82e1
更新日期:2009-10-01 00:00:00